In the first game No. 16 St. Francis (PA) will square off with No. 16 Alabama State, with a trip to Kentucky to take on the top overall seed Auburn on the line. In the second game, No. 11 North Carolina — a surprising inclusion in the tournament — takes on No.

One region in the 2025 NCAA Tournament bracket stands out above the rest for its brutality. The West is going to be a slugfest, as No. 1 seed Florida, No. 2 seed St. John's, No. 3 seed Texas Tech and No.