Researchers warn that the public, policy makers and even clinicians are not aware of the growing problem of liver cancer.

Simple lifestyle changes could drastically cut cases of liver cancer, according to academics. The Lancet Commission on liver cancer found that three in five liver cancer cases could be prevented by reducing alcohol consumption and obesity and by increasing uptake of the hepatitis vaccine.

Liver cancer is still relatively rare in the United States, representing 2.1% of all new cancer diagnoses in 2025. The report estimated that by 2040, U.S. rates of MASLD could more than double, affecting more than 55% of adults.