Take the San Francisco 49ers to cover for our NFL pick, odds & expert prediction against the Las Vegas Raiders on Saturday, August 16.

The Miami Dolphins could very well pull the plug on Tyreek Hill with teams being interested. However, in this prediction they do get trade capital.

The 49ers signed Purdy to a five-year, $265 million extension in the offseason. He is locked in as the team’s future, with Brandon Aiyuk returning from a torn ACL some point this season and Christian McCaffrey healthier to start the year.

The 49ers’ win total in Las Vegas (but let’s be honest, it’s really just on your phone) is 10.5. That’s a clear expectation from bookies and the marketplace that the Niners are expected to be a playoff team this year. But even head coach Kyle Shanahan is pumping the brakes a bit.

The Las Vegas Raiders resume Week 2 of the 2025 NFL preseason hosting the San Francisco 49ers today. Where to watch, stream and NFL preseason TV schedule.

Bleacher Report’s first 2026 NFL Mock Draft predicts the 49ers will select USC wide receiver Ja’Kobi Lane with the No. 26 overall pick.

The injury-riddled 49ers do have some players worth watching in Saturday’s preseason visit to the Raiders after possible cameos by select starters.

Target the Broncos spread for tonight's pick, odds & expert predictions against the 49ers on Saturday, August 9.