The second day of the 2025 NCAA Tournament is almost underway, and the two First Four matchups from Dayton, Ohio, will provide fireworks before Thursday's main event. No. 16 seeds Mount St. Mary's and American face off to start the day,

According to Bet MGM, the four championship favorites are, naturally, the four No. 1 seeds: Duke (+325), Florida (+325), Auburn (+400) and Houston (+600). The fifth choice on the board is No. 2 seed Alabama, sliding down significantly to +1600. Tennessee checks in at +1800, and every other option is +2500 or higher.

In the first game No. 16 St. Francis (PA) will square off with No. 16 Alabama State, with a trip to Kentucky to take on the top overall seed Auburn on the line. In the second game, No. 11 North Carolina — a surprising inclusion in the tournament — takes on No.